INITIATION CODONS WITHIN 5'-LEADERS OF MESSENGER-RNAS AS REGULATORS OF TRANSLATION

被引：202

作者：

GEBALLE, AP

MORRIS, DR

机构：

[1] FRED HUTCHINSON CANC RES CTR, DIV CLIN RES, SEATTLE, WA 98104 USA

[2] UNIV WASHINGTON, DEPT BIOCHEM, SEATTLE, WA 98195 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 04期

关键词：

D O I：

10.1016/0968-0004(94)90277-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Why should a preponderance of proto-oncogenes, growth factor genes and growth factor receptor genes contain translation initiation codons and associated open reading frames in their 5'-leaders? An increasing number of open reading frames are being shown to function as cis-acting regulatory signals able to moderate expression of the downstream reading frame. These regulatory elements could play a fundamental role in the regulation of proliferation of vertebrate cells.

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页码：159 / 164

页数：6

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