PLATINUM(II) COMPLEXES GENERATE FRAME-SHIFT MUTATIONS IN TEST STRAINS OF SALMONELLA-TYPHIMURIUM

被引：46

作者：

ANDERSEN, KS

机构：

[1] Institute of Life Sciences and Chemistry, Roskilde University, DK 4000 Roskilde

来源：

MUTATION RESEARCH | 1979年 / 67卷 / 03期

关键词：

D O I：

10.1016/0165-1218(79)90014-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

cis-Diamminodichloroplatinum(II) (cis-PDD) and diaquoethylenediamine-platinum(II) induce histidine revertants in Salmonella typhimurium strains TA98 (frame-shift mutation) and TA100 (base-pair substitution mutation). A linear dose-response relationship is found with cis-PDD acting on TA98 and TA100. Salmonella typhimurium strains TA1535, TA1537 and TA1538 are not sensitive to the mutagenic action of cis-PDD. All 5 strains are sensitive to the toxic effect of cis-PDD. Platinum(II) complexes induce mutations (frame-shift or base-pair substitution) only in strains carrying the R-factor plasmid. © 1979.

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页码：209 / 214

页数：6

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