CD40 AND ITS LIGAND, AN ESSENTIAL LIGAND RECEPTOR PAIR FOR THYMUS-DEPENDENT B-CELL ACTIVATION

被引：310

作者：

NOELLE, RJ ^{[1
]}

LEDBETTER, JA ^{[1
]}

ARUFFO, A ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,SEATTLE,WA 98121

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 11期

关键词：

D O I：

10.1016/0167-5699(92)90068-I

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The discovery of CD40 and its ligand, gp39, have created new perspectives on the activation of resting B cells by T(H) cells. Here, Randolph Noelle, Jeffrey Ledbetter and Alejandro Aruffo describe how these molecules were characterized and, from recent findings, examine their relevance to immune activation.

引用

页码：431 / 433

页数：3

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