SIGMA-RECEPTOR BLOCKADE BY BMY-14802 AFFECTS ENKEPHALINERGIC AND TACHYKININ CELLS DIFFERENTIALLY IN THE STRIATUM OF THE RAT

被引：5

作者：

ANGULO, JA ^{[1
]}

CADET, JL ^{[1
]}

MCEWEN, BS ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL,PRECLIN NEUROSCI LAB,NEW YORK,NY 10032

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 175卷 / 02期

关键词：

(In situ hybridization); BMY; 14802; Neuroleptics; Proenkephalin; Protachykinin;

D O I：

10.1016/0014-2999(90)90236-Y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We determined proenkephalin and protachykinin mRNA levels in the striatum of the rat by in situ hybridization histochemistry in controls and in animals treated for 14 days with the potential neuroleptic drug BMY 14802 (15 mg/kg i.p.). Proenkephalin mRNA levels were increased relative to control values by 107, 88 and 94% and protachykinin mRNA levels decreased by 17, 28 and 10% in the rostral, medial and caudal aspects of the caudate-putamen, respectively. The data suggest that σ receptor activity, directly or indirectly, affects proenkephalin and protachykinin mRNA expression in striatal neurons. © 1990.

引用

页码：225 / 228

页数：4

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