LYSOPHOSPHATIDYLCHOLINE AS A POSSIBLE 2ND MESSENGER SYNERGISTIC TO DIACYLGLYCEROL AND CALCIUM-ION FOR LYMPHOCYTE-T ACTIVATION

被引：45

作者：

ASAOKA, Y ^{[1
]}

OKA, M ^{[1
]}

YOSHIDA, K ^{[1
]}

NISHIZUKA, Y ^{[1
]}

机构：

[1] KOBE UNIV,SCH MED,DEPT BIOCHEM,KOBE 650,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 178卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)91046-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An immediate reaction product of phosphatidylcholine hydrolysis catalyzed by phospholipase A2, lysophosphatidylcholine (lysoPC), synergizes with a membrane-permeable diacylglycerol, 1,2-dioctanoylglycerol, and ionomycin to activate resting T-lymphocytes as measured by interleukin-2 α-receptor expression. It is suggestive that both phospholipase C and phospholipase A2 are directly involved in signal transduction in a synergistic fashion and that lysoPC acts as an additional second messenger for cellular regulation, probably for long-term responses such as cell proliferation and differentiation. © 1991.

引用

页码：1378 / 1385

页数：8

共 19 条

[1] RECEPTOR-MEDIATED ACTIVATION OF PHOSPHOLIPASE-A2 VIA GTP-BINDING PROTEINS - ARACHIDONIC-ACID AND ITS METABOLITES AS 2ND MESSENGERS [J].