EFFECTS OF ACETYLCHOLINE AND NOREPINEPHRINE ON CA-45 UPTAKE AND EFFLUX IN RABBIT IRIS SMOOTH-MUSCLE

被引：7

作者：

AKHTAR, RA

ABDELLATIF, AA

机构：

[1] Department of Cell and Molecular Biology, Medical College of Georgia, Augusta

来源：

GENERAL PHARMACOLOGY | 1979年 / 10卷 / 06期

关键词：

D O I：

10.1016/0306-3623(79)90006-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effects of acetylcholine and norepinephrine on uptake and efflux of 45Ca in rabbit iris muscle were investigated. 2. The uptake of 45Ca was studied by the La+ method". LaCl3 (10 mM) effectively displaced the extracellular 45Ca and inhibited both uptake and efflux of 45Ca in the tissue. 3. Acetylcholine (50 μM) increased 45Ca uptake and decreased 45Ca efflux and this effect was inhibited by atropine (20 μM). 4. Norepinephrine (100 μM) decreased 45Ca uptake and increased 45Ca efflux and this effect was blocked by phentolamine (100 μM). © 1979."

引用

页码：445 / 450

页数：6

共 23 条

[1] NOREPINEPHRINE-STIMULATED BREAKDOWN OF TRIPHOSPHOINOSITIDE OF RABBIT IRIS SMOOTH-MUSCLE - EFFECTS OF SURGICAL SYMPATHETIC DENERVATION AND INVIVO ELECTRICAL-STIMULATION OF SYMPATHETIC-NERVE OF EYE [J].