T-CELL UNRESPONSIVENESS CORRELATES WITH QUANTITATIVE TCR LEVELS IN A TRANSGENIC MODEL

被引：19

作者：

HOMER, RJ

MAMALAKI, C

KIOUSSIS, D

FLAVELL, RA

机构：

[1] YALE UNIV, SCH MED, IMMUNOBIOL SECT, NEW HAVEN, CT 06510 USA

[2] NATL INST MED RES, LONDON NW7 1AA, ENGLAND

[3] YALE UNIV, SCH MED, HOWARD HUGHES MED INST, NEW HAVEN, CT 06510 USA

来源：

INTERNATIONAL IMMUNOLOGY | 1993年 / 5卷 / 12期

关键词：

T-CELL DEVELOPMENT; TCR GENETICS; TOLERANCE; TRANSGENIC ANIMAL MOUSE;

D O I：

10.1093/intimm/5.12.1495

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two lines of transgenic mice were developed which differ in their level of expression of V(beta)11. To determine the role of TCR density in tolerance induction, these mice were bred with I-E expressing mice and were investigated for tolerance induction. T cells expressing V(beta)11 at high density are deleted by negative selection. T cells expressing < 10% of the normal TCR receptor density are not subject to negative selection and were not activated in vitro. There is a correlation in receptor density in both strains of mice with in vitro activation. These findings support the notion that there is a definable quantitative signal threshold which is critical for tolerance induction.

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页码：1495 / 1500

页数：6

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