REGULATION OF RAS-MEDIATED SIGNALING - MORE THAN ONE-WAY TO SKIN A CAT

被引：283

作者：

BURGERING, BMT

BOS, JL

机构：

[1] Laboratory of Physiological Chemistry, Utrecht University, Utrecht

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 01期

关键词：

D O I：

10.1016/S0968-0004(00)88944-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A powerful combination of genetics and biochemistry has provided details of how Ras-directed signalling interacts with and is regulated by other cellular signalling pathways. This might ultimately lead to the control of deregulated signalling by oncogenic Ras. Recently, progress has been made in understanding the regulation of Ras-mediated activation of the RaF-1-ERK2 kinase cascade through crosstalk with protein kinase C and cyclic-AMP-dependent protein kinase.

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页码：18 / 22

页数：5

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