REGULATION OF THE HUMAN NEUTROPHIL NADPH OXIDASE BY THE RAC GTP-BINDING PROTEINS

被引：127

作者：

BOKOCH, GM ^{[1
]}

机构：

[1] SCRIPPS RES INST, DEPT CELL BIOL, LA JOLLA, CA 92037 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 02期

关键词：

D O I：

10.1016/0955-0674(94)90138-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent progress in our understanding of the regulation of the phagocyte NADPH oxidase by the Rac GTP-binding protein(s) has provided the first detailed glimpse into the mechanisms of leukocyte regulation by a small GTP-binding protein. Studies over the past year have indicated that the activity of the NADPH oxidase can be modulated by regulation of the GTP/GDP state of Rac. Proteins exist in leukocytes that are able to modify GTP-binding protein function in this manner, and their activity may be regulated by signals generated upon phagocyte stimulation.

引用

页码：212 / 218

页数：7

共 43 条

[1]

ABO A, 1991, J BIOL CHEM, V266, P23577

[2] ACTIVATION OF THE NADPH OXIDASE INVOLVES THE SMALL GTP-BINDING PROTEIN P21RAC1 [J].

ABO, A ;

PICK, E ;

HALL, A ;

TOTTY, N ;

TEAHAN, CG ;

SEGAL, AW .

NATURE, 1991, 353 (6345) :668-670

[3]

ADO A, 1992, J BIOL CHEM, V267, P16767

[4]

ANDO S, 1992, J BIOL CHEM, V267, P25709

[5] ACTIVATION OF NEUTROPHIL LEUKOCYTES - CHEMOATTRACTANT RECEPTORS AND RESPIRATORY BURST [J].

BAGGIOLINI, M ;

BOULAY, F ;

BADWEY, JA ;

CURNUTTE, JT .

FASEB JOURNAL, 1993, 7 (11) :1004-1010

[6] ISOPRENOID METABOLISM IS REQUIRED FOR STIMULATION OF THE RESPIRATORY BURST OXIDASE OF HL-60 CELLS [J].

BOKOCH, GM ;

PROSSNITZ, V .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (02) :402-408

[7] EMERGING CONCEPTS IN THE RAS SUPERFAMILY OF GTP-BINDING PROTEINS [J].

BOKOCH, GM ;

DER, CJ .

FASEB JOURNAL, 1993, 7 (09) :750-759

[8]

BOLSCHER BGJM, 1990, J BIOL CHEM, V265, P15782

[9] COPURIFICATION OF RHO PROTEIN AND THE RHO-GDP DISSOCIATION INHIBITOR FROM BOVINE NEUTROPHIL CYTOSOL - EFFECT OF PHOSPHOINOSITIDES ON RHO ADP-RIBOSYLATION BY THE C3 EXOENZYME OF CLOSTRIDIUM-BOTULINUM [J].

BOURMEYSTER, N ;

STASIA, MJ ;

GARIN, J ;

GAGNON, J ;

BOQUET, P ;

VIGNAIS, PV .

BIOCHEMISTRY, 1992, 31 (51) :12863-12869

[10]

CHAUNG T, 1993, J BIOL CHEM, V268, P775

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