SHARING OF THE INTERLEUKIN-2 (IL-2) RECEPTOR GAMMA-CHAIN BETWEEN RECEPTORS FOR IL-2 AND IL-4

被引：769

作者：

KONDO, M

TAKESHITA, T

ISHII, N

NAKAMURA, M

WATANABE, S

ARAI, K

SUGAMURA, K

机构：

[1] TOHOKU UNIV,SCH MED,DEPT MICROBIOL,SENDAI,MIYAGI 980,JAPAN

[2] UNIV TOKYO,INST MED SCI,DEPT MOLEC & DEV BIOL,TOKYO 108,JAPAN

来源：

SCIENCE | 1993年 / 262卷 / 5141期

关键词：

D O I：

10.1126/science.8266076

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The gamma chain of the interleukin-2 (IL-2) receptor is an indispensable subunit for IL-2 binding and intracellular signal transduction. A monoclonal antibody to the gamma chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also inhibited IL-4-induced cell growth and the high-affinity binding of IL-4 to the CTLL-2 mouse T cell line. Another monoclonal antibody, TUGm3, which reacted with the gamma chain cross-linked with IL-2, also immunoprecipitated the gamma chain when cross-linked with IL-4. These results suggest that the IL-2 receptor gamma chain is functionally involved in the IL-4 receptor complex.

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页码：1874 / 1877

页数：4

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