MAMMALIAN NEUROTROPHIN-4 - STRUCTURE, CHROMOSOMAL LOCALIZATION, TISSUE DISTRIBUTION, AND RECEPTOR SPECIFICITY

被引：566

作者：

IP, NY

IBANEZ, CF

NYE, SH

MCCLAIN, J

JONES, PF

GIES, DR

BELLUSCIO, L

LEBEAU, MM

ESPINOSA, R

SQUINTO, SP

PERSSON, H

YANCOPOULOS, GD

机构：

[1] UNIV CHICAGO,DEPT MED,DIV HEMATOL ONCOL,CHICAGO,IL 60637

[2] KAROLINSKA INST,DEPT MED CHEM,MOLEC NEUROBIOL LAB,S-10401 STOCKHOLM 60,SWEDEN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 07期

关键词：

NERVE GROWTH FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN-3; TRK RECEPTOR; PROCESSING;

D O I：

10.1073/pnas.89.7.3060

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the three members of the neurotrophin family known to exist in mammals. Recently, a fourth neurotrophin (designated neurotrophin-4 or NT-4), which shares all of the features found in the mammalian neurotrophins, has been identified in Xenopus and viper. We used sequences specific to the Xenopus/viper NT-4 to isolate a neurotrophin from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4. Human NT-4 as well as a human NT-4 pseudogene colocalize to chromosome 19 band q13.3. Mammalian NT-4 has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophins. However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4.

引用

页码：3060 / 3064

页数：5

共 32 条

[1] NEUROTROPHIN-5 - A NOVEL NEUROTROPHIC FACTOR THAT ACTIVATES TRK AND TRKB [J].