EFFECT OF DIPYRIDAMOLE AND 2 PYRIMIDO-PYRIMIDINE DERIVATIVES ON KINETICS OF HUMAN PLATELET AGGREGATION AND ON PLATELET ADHESIVENESS

被引：34

作者：

ELIASSON, R

BYGDEMAN, S

机构：

[1] Department of Physiology, Karolinska Institutet, Faculty of Medicine, Stockholm

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1969年 / 24卷 / 02期

关键词：

Blood platelet adhesiveness; Blood platelet aggregative; Pyrimidines;

D O I：

10.3109/00365516909080145

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Dipyramidole and two new derivatives (RA 233 and 433) were compared as regards their inhibitory action on ADP- and noradrenaline-induced platelet aggregation and adhesiveness in vitro. Aggregation was studied with a turbidometric method allowing accurate kinetic studies. Platelet adhesiveness and aggregation were markedly inhibited by RA 233 and RA 433 (5-50 μg/ml) while dipyridamole (50-100 μg/ml) only had a weak and irregular effect. The rate of disaggregation was not influenced. © 1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：145 / &

共 14 条

[1]

ALSHABKHOUN S, 1967, AM J CARDIOL, V19, P325

[2] AGGREGATION OF BLOOD PLATELETS BY ADENOSINE DIPHOSPHATE AND ITS REVERSAL [J].