THE COMBINATION OF NMDA ANTAGONISM AND MORPHINE PRODUCES PROFOUND ANTINOCICEPTION IN THE RAT DORSAL HORN

被引：180

作者：

CHAPMAN, V

DICKENSON, AH

机构：

[1] Department of Pharmacology, University College London, London

来源：

BRAIN RESEARCH | 1992年 / 573卷 / 02期

基金：

英国医学研究理事会;

关键词：

N-METHYL-D-ASPARTATE RECEPTOR; NOCICEPTION; MORPHINE; SPINAL CORD; WIND UP; C-FIBER RESPONSE;

D O I：

10.1016/0006-8993(92)90780-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dorsal horn nociceptive neurones exhibit wind up, a frequency dependent potentiation of their responses to repeated C-fibre stimulation. Intrathecal morphine (5-mu-g) significantly reduces the initial responses of the neurones but not wind up whereas the reverse is true for N-methyl-D-aspartate (NMDA) antagonists. The combination of intrathecal morphine (5-mu-g) and 7-chlorokynurenate (2.5-mu-g), an antagonist at the glycine site of the NMDA receptor, abolishes both the input and wind up of these neurones.

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收藏

页码：321 / 323

页数：3

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