FUNCTION OF A HUMAN CYCLIN GENE AS AN ONCOGENE

被引:477
作者
HINDS, PW
DOWDY, SF
EATON, EN
ARNOLD, A
WEINBERG, RA
机构
[1] WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA 02142 USA
[2] MASSACHUSETTS GEN HOSP, ENDOCRINE ONCOL LAB, BOSTON, MA 02114 USA
[3] HARVARD UNIV, SCH MED, BOSTON, MA 02114 USA
关键词
D O I
10.1073/pnas.91.2.709
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene. In such cells, this candidate oncogene indeed functions like an oncogene, suggesting a similar role in tumor progression in vivo.
引用
收藏
页码:709 / 713
页数:5
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