FUNCTION OF A HUMAN CYCLIN GENE AS AN ONCOGENE

被引：477

作者：

HINDS, PW

DOWDY, SF

EATON, EN

ARNOLD, A

WEINBERG, RA

机构：

[1] WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA 02142 USA

[2] MASSACHUSETTS GEN HOSP, ENDOCRINE ONCOL LAB, BOSTON, MA 02114 USA

[3] HARVARD UNIV, SCH MED, BOSTON, MA 02114 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 02期

关键词：

D O I：

10.1073/pnas.91.2.709

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene. In such cells, this candidate oncogene indeed functions like an oncogene, suggesting a similar role in tumor progression in vivo.

引用

收藏

页码：709 / 713

页数：5

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