CLINICAL-EXPERIENCE WITH PEDVAXHIB, A CONJUGATE VACCINE OF HAEMOPHILUS-INFLUENZAE TYPE-B POLYSACCHARIDE NEISSERIA-MENINGITIDIS OUTER-MEMBRANE PROTEIN

被引：16

作者：

AHONKHAI, VI ^{[1
]}

LUKACS, LJ ^{[1
]}

JONAS, LC ^{[1
]}

CALANDRA, GB ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,W POINT,PA 19486

来源：

VACCINE | 1991年 / 9卷

关键词：

HAEMOPHILUS-INFLUENZAE CONJUGATE; CLINICAL EXPERIENCE;

D O I：

10.1016/0264-410X(91)90180-E

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

PedvaxHIB, a Haemophilus influenzae type b (Hib) conjugate vaccine composed of Hib capsular polysaccharide covalently bound to an outer membrane protein complex of Neisseria meningitidis serogroup B, was evaluated for immunogenicity and safety in infants and children 2 months of age and older. A significant and consistent antibody response was seen after a single dose of the vaccine in all age groups, including infants as young as 2 months of age. In addition, the vaccine elicited a good booster response when given at 12 to 17 months of age. Subjects from diverse subpopulations, including those with impaired antibody response to Hib polysaccharide vaccines, showed a significant response to vaccination. The vaccine was well tolerated when administered alone or concurrently with other paediatric vaccines. A protective efficacy study, recently completed, has shown the vaccine to be highly effective in 2-month-old infants.

引用

页码：S38 / S41

页数：4

共 16 条

[1]

AHONKHAI VI, 1990, PEDIATRICS, V85, P676

[2]

CAMPBELL H, 1990, PEDIATRICS, V86, P102

[3]

DASHEFSKY B, 1990, PEDIATRICS, V85, P682

[4]

GILBERT GL, 1990, VACCINE, pS10