PROPRANOLOL, CHLORPROMAZINE AND PLATELET MEMBRANE - FLUORESCENCE STUDY OF THE DRUG-MEMBRANE INTERACTION

被引：44

作者：

DACHARYPRIGENT, J ^{[1
]}

DUFOURCQ, J ^{[1
]}

LUSSAN, C ^{[1
]}

BOISSEAU, M ^{[1
]}

机构：

[1] CTR RECH PAUL PASCAL,DOMAINE UNIVERSITAIRE,F-33400 TALENCE,FRANCE

来源：

THROMBOSIS RESEARCH | 1979年 / 14卷 / 01期

关键词：

D O I：

10.1016/0049-3848(79)90020-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The binding of propranolol 1 μM (PRO) and chlorpromazine 35 μM (CPZ) was studied on liposomes of the main platelet phospholipids: phosphatidylcholine (PC), phosphatidylethanolamine (PE) phosphatidylserine (PS), phosphatidylinositol (PI) and sphingomyelin (SPH), on the pool of platelet extracted phospholipids (PPL) and on platelet membrane (PM) by means of the fluorescence emission properties of the two drugs. We concluded that PRO and CPZ bind preferentially with PS and PI which are localized in the inner bilayer of the platelet membrane. This result is the first experimental evidence of the suggestion of many authors that cationic drugs bind to negative phospholipids. © 1979.

引用

页码：15 / 22

页数：8

共 23 条

[1]

BARBER AJ, 1970, J BIOL CHEM, V245, P6357

[2]

BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911

[3]

Bottcher C. J. F., 1961, ANAL CHIM ACTA, V24, P203

[4]

BRETON J, 1977, ARCH BIOCH BIOPHYS, V179, P525

[5] ACTION OF HIGHLY PURIFIED PHOSPHOLIPASES ON BLOOD-PLATELETS - EVIDENCE FOR AN ASYMMETRIC DISTRIBUTION OF PHOSPHOLIPIDS IN SURFACE-MEMBRANE [J].

CHAP, HJ ;

ZWAAL, RFA ;

VANDEENEN, LLM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 467 (02) :146-164

[6] FLUORESCENCE STUDIES OF MEMBRANE INTERACTIONS OF CHLORPROMAZINE AND CHLORIMIPRAMINE [J].

ELFERINK, JGR .

BIOCHEMICAL PHARMACOLOGY, 1977, 26 (06) :511-515

[7] ASYMMETRIC DISTRIBUTION OF CHLORPROMAZINE AND ITS QUATERNARY ANALOG OVER ERYTHROCYTE-MEMBRANE [J].

ELFERINK, JGR .

BIOCHEMICAL PHARMACOLOGY, 1977, 26 (24) :2411-2416

[8] CALORIMETRIC, C-13 NMR, AND P-31 NMR-STUDIES ON INTERACTION OF SOME PHENOTHIAZINE DERIVATIVES WITH DIPALMITOYL PHOSPHATIDYLCHOLINE MODEL MEMBRANES [J].

FRENZEL, J ;

ARNOLD, K ;

NUHN, P .

BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 507 (02) :185-197

[9]

FUJITA S, 1976, ARCH INT PHARMACOD T, V220, P28

[10] STUDIES ON INTERACTION OF PROPRANOLOL WITH ERYTHROCYTE-MEMBRANES [J].

GODIN, DV ;

NG, TW ;

TUCHEK, JM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 436 (04) :757-773

← 1 2 3 →