NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCE OF PORCINE INTERLEUKIN 4 CDNA DERIVED FROM LAMINA PROPRIA LYMPHOCYTES

被引：17

作者：

BAILEY, M ^{[1
]}

PERRY, ACF ^{[1
]}

BLAND, PW ^{[1
]}

STOKES, CR ^{[1
]}

HALL, L ^{[1
]}

机构：

[1] UNIV BRISTOL,DEPT BIOCHEM,BRISTOL BS8 1TH,AVON,ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1171卷 / 03期

关键词：

INTERLEUKIN-4; CYTOKINE; LYMPHOCYTE; INTESTINE; (PIG);

D O I：

10.1016/0167-4781(93)90077-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Total RNA was isolated from in vitro activated lamina propria lymphocytes and used to direct the synthesis of cDNA. Interleukin 4 transcripts were then specifically amplified by PCR. Comparison of the nucleotide sequence with its human homologue demonstrates deletion within the coding region of pig interleukin 4 centred around amino acid residue 70 in the mature human protein.

引用

页码：328 / 330

页数：3

共 20 条

[1] INTERLEUKIN-2, INTERLEUKIN-4 AND INTERLEUKIN-5 ARE SEQUENTIALLY PRODUCED IN MITOGEN-STIMULATED MURINE SPLEEN-CELL CULTURES [J].

CARDELL, S ;

SANDER, B .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (02) :389-395

[2]

COFFMAN RL, 1986, J IMMUNOL, V136, P4538

[3] REGULATION OF MURINE LYMPHOKINE PRODUCTION INVIVO .3. THE LYMPHOID-TISSUE MICROENVIRONMENT EXERTS REGULATORY INFLUENCES OVER T-HELPER CELL-FUNCTION [J].

DAYNES, RA ;

ARANEO, BA ;

DOWELL, TA ;

HUANG, K ;

DUDLEY, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (04) :979-996

[4] CDNA CLONING OF PORCINE INTERLEUKIN-2 BY POLYMERASE CHAIN-REACTION [J].

GOODALL, JC ;

EMERY, DC ;

BAILEY, M ;

ENGLISH, LS ;

HALL, L .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1089 (02) :257-258

[5] RECIPROCAL EXPRESSION OF INTERFERON-GAMMA OR INTERLEUKIN-4 DURING THE RESOLUTION OR PROGRESSION OF MURINE LEISHMANIASIS - EVIDENCE FOR EXPANSION OF DISTINCT HELPER T-CELL SUBSETS [J].

HEINZEL, FP ;

SADICK, MD ;

HOLADAY, BJ ;

COFFMAN, RL ;

LOCKSLEY, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (01) :59-72

[6] CLONING OF A FULL-LENGTH CDNA-ENCODING BOVINE INTERLEUKIN-4 BY THE POLYMERASE CHAIN-REACTION [J].

HEUSSLER, VT ;

EICHHORN, M ;

DOBBELAERE, DAE .

GENE, 1992, 114 (02) :273-278

[7] IDENTIFICATION OF A T-CELL-DERIVED B-CELL GROWTH-FACTOR DISTINCT FROM INTERLEUKIN-2 [J].

HOWARD, M ;

FARRAR, J ;

HILFIKER, M ;

JOHNSON, B ;

TAKATSU, K ;

HAMAOKA, T ;

PAUL, WE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 155 (03) :914-923

[8] T-CELL-DERIVED B-CELL DIFFERENTIATION FACTOR(S) - EFFECT ON THE ISOTYPE SWITCH OF MURINE B-CELLS [J].

ISAKSON, PC ;

PURE, E ;

VITETTA, ES ;

KRAMMER, PH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 155 (03) :734-748

[9]

JAMES SP, 1990, J IMMUNOL, V144, P1251

[10] CONVERSION OF HUMAN INTERLEUKIN-4 INTO A HIGH-AFFINITY ANTAGONIST BY A SINGLE AMINO-ACID REPLACEMENT [J].

KRUSE, N ;

TONY, HP ;

SEBALD, W .

EMBO JOURNAL, 1992, 11 (09) :3237-3244

← 1 2 →