FREE-RADICALS AND INFLAMMATION - PROTECTION OF SYNOVIAL-FLUID BY SUPEROXIDE-DISMUTASE

被引：1040

作者：

MCCORD, JM

机构：

[1] DUKE UNIV, MED SCH, DEPT BIOCHEM, DURHAM, NC 27710 USA

[2] DUKE UNIV, MED CTR, DEPT MED, DURHAM, NC 27710 USA

来源：

SCIENCE | 1974年 / 185卷 / 4150期

关键词：

D O I：

10.1126/science.185.4150.529

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Enzymatically generated superoxide radical, by reacting with hydrogen peroxide to produce the hydroxyl radical, depolymerized purified hyaluronic acid and bovine synovial fluid. Since phagocytizing polymorphonuclear leukocytes produce superoxide radicals, this reaction is suggested and shown to be quantitatively feasible as the in vivo mechanism of synovial fluid degradation in an inflamed joint. Superoxide dismutase and catalase protect synovial fluid against such degradation in vitro.

引用

页码：529 / 531

页数：3

共 18 条

[1]

ARONSON NN, 1967, J BIOL CHEM, V242, P441

[2] REDUCTION OF PARAQUAT TOXICITY BY SUPEROXIDE-DISMUTASE [J].