SOMATOSTATIN HYPERPOLARIZES HIPPOCAMPAL PYRAMIDAL CELLS-INVITRO

被引：205

作者：

PITTMAN, QJ ^{[1
]}

SIGGINS, GR ^{[1
]}

机构：

[1] UNIV CALGARY, FAC MED, DEPT PHARMACOL & THERAPEUT, CALGARY T2N 1N4, ALBERTA, CANADA

来源：

BRAIN RESEARCH | 1981年 / 221卷 / 02期

关键词：

D O I：

10.1016/0006-8993(81)90791-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Superfusion onto rat hippocampal slices of low concentrations of the tetradecapeptide somatostatin (SS), or an SS analog having CNS activity, reversibly hyperpolarized pyramidal neurons, as revealed by intracellular recording. The hyperpolarizations were accompanied by reductions in spontaneous and evoked spike discharge and in input resistance; the magnitude of the hyperpolarizations was not influenced by 10 mM MgCl2 added to the perfusate to block synaptic transmission.

引用

页码：402 / 408

页数：7

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