BASAL FOREBRAIN STIMULATION MODIFIES AUDITORY-CORTEX RESPONSIVENESS BY AN ACTION AT MUSCARINIC RECEPTORS

被引：114

作者：

METHERATE, R ^{[1
]}

ASHE, JH ^{[1
]}

机构：

[1] UNIV CALIF RIVERSIDE,DEPT PSYCHOL,PROGRAM NEUROSCI 075,RIVERSIDE,CA 92521

来源：

BRAIN RESEARCH | 1991年 / 559卷 / 01期

关键词：

BASAL FOREBRAIN; NUCLEUS BASALIS; RAT; ACETYLCHOLINE; MUSCARINIC RECEPTOR; AUDITORY CORTEX;

D O I：

10.1016/0006-8993(91)90301-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have hypothesized that auditory cortex plasticity involves modification of thalamocortical transmission by basal forebrain (BF) cholinergic neurons, and that this action may involve muscarinic receptors. In a first test of this hypothesis, we report that BF stimulation can suppress or facilitate, depending on the intensity of stimulation, auditory cortical responses elicited by thalamic stimulation. BF-mediated facilitation is antagonized by atropine, implicating muscarinic receptors. These data suggest that BF cholinergic neurons functionally modify auditory cortex by regulating thalamocortical transmission.

引用

页码：163 / 167

页数：5

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