POSTTRANSLATIONAL MODIFICATIONS IN THE COLLAGEN OF HUMAN OSTEOPOROTIC FEMORAL-HEAD

被引：91

作者：

BAILEY, AJ ^{[1
]}

WOTTON, SF ^{[1
]}

SIMS, TJ ^{[1
]}

THOMPSON, PW ^{[1
]}

机构：

[1] ROYAL LONDON HOSP,COLL MED,ARC BONE & JOINT UNIT,LONDON E1 2AD,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 185卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)91697-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

No detailed biochemical analysis has been made of the possible compositional changes in the collagen relating to the fragility of osteoporotic bone. We report for the first time significant changes in the compositional properties of the collagen. The major differences were observed in the post-translational modifications, namely, in the hydroxylation of lysine residues and the nature of the stabilizing cross-links of the collagen fibre. The increase in hydroxylation was greater in the head region compared to the neck region of the femoral head, whilst the decrease in the intermediate cross-links was greater in the neck region. Clearly, the collagen is altered in osteoporosis and it is important that these changes are recognised in studies of bone metabolism in osteoporosis since they may play a role in the pathogenesis of the disease. © 1992.

引用

页码：801 / 805

页数：5

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