INVIVO ENHANCEMENT OF DENGUE VIRUS-INFECTION IN RHESUS-MONKEYS BY PASSIVELY TRANSFERRED ANTIBODY

被引：366

作者：

HALSTEAD, SB

机构：

[1] Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI

来源：

JOURNAL OF INFECTIOUS DISEASES | 1979年 / 140卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/infdis/140.4.527

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Five pairs of juvenile, dengue virus-susceptible rhesus monkeys were given normal or dengue-immune human cord-blood serum injected intravenously to a final dilution of 1:300. The pool of immune human cord-blood serum had a titer of antibody to dengue type 2 virus (D2V) of 1:140 in the plaque-reduction neutralization test and a titer of human monocyte infection enhancement of >1:2, 000, 000. Fifteen minutes after inoculation of serum, animals were infected with D2V (strain no. 16681). Daily titers of viremia were always higher in the animals that had received antiserum to D2V than in animals that had received normal cord-blood serum. Ratios of infection enhancement ranged from 2.7 to 51.4. The demonstration of antibody dependence of dengue virus infection in subhuman primates-a complex, outbred experimental host-supports the hypothesis that the severity of dengue in humans is regulated by antibody. © 1979 by The University of Chicago.

引用

页码：527 / 533

页数：7

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