ASSOCIATION OF AMYLOID-P COMPONENT WITH COMPLEMENT PROTEINS IN NEUROLOGICALLY DISEASED BRAIN-TISSUE

被引：49

作者：

AKIYAMA, H ^{[1
]}

YAMADA, T ^{[1
]}

KAWAMATA, T ^{[1
]}

MCGEER, PL ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT PSYCHIAT,KINSMEN LAB NEUROL RES,2255 WESBROOK MALL,VANCOUVER V6T 1W5,BC,CANADA

来源：

BRAIN RESEARCH | 1991年 / 548卷 / 1-2期

关键词：

AMYLOID-P; COMPLEMENT; ALZHEIMERS DISEASE; OLIGODENDROGLIA;

D O I：

10.1016/0006-8993(91)91148-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amyloid P component (AP) was detected in a number of lesions in human brain associated with chronic degenerative disease. These lesions included diffuse and consolidated amyloid deposits, cerebral amyloid angiopathy, neurofibrillary tangles, neuropil threads and complement activated oligodendroglia. The staining for AP generally paralleled that for complement proteins C4d and C3d, suggesting that AP may serve as an adjuvant for phagocytosis.

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页码：349 / 352

页数：4

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