ENHANCED ANALGESIC EFFECTS OF STRESS FOLLOWING CHRONIC ADMINISTRATION OF NALTREXONE IN RATS

被引：28

作者：

AMIR, S

AMIT, Z

机构：

[1] Center for Research on Drug Dependence, Department of Psychology, Concordia University, Montréal, Que. H3G 1M8

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 59卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

Chronic naltrexone; Hot-plate test; Opiate receptor supersensitivity; Stress-induced analgesia;

D O I：

10.1016/0014-2999(79)90036-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic administration of the long acting opiate antagonist naltrexone potentiated the analgesic effects of foot-shock stress in the hot-plate test in rats. No changes in pain responsiveness were noted in naltrexone-treated rats that were not subjected to the foot-shock treatment. The results suggest that chronic opiate receptor may lead to the development of supersensitivity in endogenous opiate systems that mediate the analgesic effects of stress. © 1979.

引用

页码：137 / 140

页数：4

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