ATTACHMENT OF RAT HEPATOCYTES TO COLLAGEN AND FIBRONECTIN - STUDY USING ANTIBODIES DIRECTED AGAINST CELL-SURFACE COMPONENTS

被引：75

作者：

RUBIN, K ^{[1
]}

JOHANSSON, S ^{[1
]}

PETTERSSON, I ^{[1
]}

OCKLIND, C ^{[1
]}

OBRINK, B ^{[1
]}

HOOK, M ^{[1
]}

机构：

[1] UNIV UPPSALA,DEPT PHYSIOL CHEM,S-75105 UPPSALA,SWEDEN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 01期

关键词：

D O I：

10.1016/0006-291X(79)90586-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Attachment of rat hepatocytes to collagen but not to fibronectin substrata was efficiently inhibited by antibodies against the hepatocyte surface. Further analyses of this inhibition suggested that hepatocyte attachment to collagen involves cell surface antigens which are not identical to membrane bound fibronectin or collagen. Rabbit antibodies against rat fibronectin inhibited hepatocyte attachment to rat fibronectin but not to collagen or rabbit fibronectin. After plasmin digestion of fibronectin, peptides were isolated that lacked affinity for collagen but could serve as a substratum for hepatocyte attachment. These results suggested that attachment to fibronectin does not involve membrane bound fibronectin or collagen. © 1979.

引用

页码：86 / 94

页数：9

共 19 条

[1]

BENSUSAN HB, 1978, P NATL ACAD SCI US, V75, P5064

[2] BINDING OF SOLUBLE FORM OF FIBROBLAST SURFACE PROTEIN, FIBRONECTIN, TO COLLAGEN [J].