SCINTIGRAPHIC INVESTIGATION OF THE GASTRIC-EMPTYING OF 3-MM PELLETS IN HUMAN VOLUNTEERS

被引：8

作者：

BLOK, D

ARNDT, JW

DEHAAN, FHN

VERMEIJ, P

JUNGINGER, HE

PAUWELS, EKJ

机构：

[1] LEIDEN UNIV HOSP,DEPT DIAGNOST RADIOL,DIV NUCL MED,2333 AA LEIDEN,NETHERLANDS

[2] LEIDEN UNIV HOSP,CTR BIOPHARMACEUT SCI,DIV PHARMACEUT TECHNOL,2333 AA LEIDEN,NETHERLANDS

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 73卷 / 02期

关键词：

GASTRIC EMPTYING; SCINTIGRAPHY; CONTROLLED RELEASE; PELLET; GASTROINTESTINAL TRANSIT; FOOD;

D O I：

10.1016/0378-5173(91)90041-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The gastric residence time of a coated pellet formulation has been investigated in six human volunteers. After labelling with the radionuclide Tc-99m, the pellets were coated with a methacrylic acid resin and the gastric emptying from a fed stomach was measured by gamma scintigraphy. Four volunteers showed extremely slow emptying, two subjects showed substantial gastric emptying after 3 h.

引用

页码：171 / 176

页数：6

共 13 条

[1] THE USE OF GAMMA-SCINTIGRAPHY TO FOLLOW THE GASTROINTESTINAL TRANSIT OF PHARMACEUTICAL FORMULATIONS [J].