EFFECT OF INSULIN ON GLUCAGON ENHANCED LIPOLYSIS IN VITRO

被引：32

作者：

LEFEBVRE, PJ

LUYCKX, AS

机构：

[1] Institut de Médecine, Département de Clinique et de Pathologie Médicales, Secteur Diabétologie, Université de Liège

来源：

DIABETOLOGIA | 1969年 / 5卷 / 03期

关键词：

adipose tissue; FFA; glucagon; Insulin; lipolysis;

D O I：

10.1007/BF01213680

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucagon in concentrations similar to those found in human plasma markedly stimulates lipolysis in rat adipose tissue in vitro. The effects of these physiological" concentrations of glucagon are reduced or abolished by insulin at concentrations of 25 and 100 μU/ml. Considering the marked insulinogenic effect of glucagon these observations may provide an explanation for the delayed increase of blood FFA observed after glucagon injection in vivo. © 1969 Springer-Verlag."

引用

页码：195 / &

共 24 条

[1]

BERGMEYER HU, 1963, METHODS ENZYMATIC ED, P215

[2] EFFECT OF GLUCAGON ON SERUM INSULIN PLASMA GLUCOSE AND FREE FATY ACIDS IN MAN [J].

CROCKFORD, PM ;

PORTE, D ;

WOOD, FC ;

WILLIAMS, RH .

METABOLISM, 1966, 15 (02) :114-+

[3] ANTILIPOLYTIC EFFECT OF INSULIN IN ISOLATED FAT CELLS OF RAT [J].

FAIN, JN ;

KOVACEV, VP ;

SCOW, RO .

ENDOCRINOLOGY, 1966, 78 (04) :773-+

[4]

HAGEN JH, 1961, J BIOL CHEM, V236, P1023

[5]

HOHORST HJ, 1963, METHOD ENZYMAT AN, P215

[6] STUDIES ON METABOLISM OF ADIPOSE TISSUE .12. EFFECTS OF INSULIN AND EPINEPHRINE ON FREE FATTY ACID AND GLYCEROL PRODUCTION IN PRESENCE AND ABSENCE OF GLUCOSE [J].

JUNGAS, RL ;

BALL, EG .

BIOCHEMISTRY, 1963, 2 (02) :383-&

[7] RADIOIMMUNOASSAYABLE GLUCAGON LEVELS IN MAN - EFFECTS OF STARVATION HYPOGLYCEMIA AND GLUCOSE ADMINISTRATION [J].

LAWRENCE, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1966, 55 (02) :316-&

[8]

LEFEBVRE P, 1965, ANN ENDOCRINOL-PARIS, V26, P602

[9]

LEFEBVRE P, 1967, GLUCAGON SECONDE HOR

[10] INFLUENCE DU GLUCAGON SUR LE DEBIT CIRCULATOIRE PANCREATICO-DUODENAL ET SUR LINSULINEMIE DU SANG VEINEUX PANCREATIQUE DU CHIEN [J].

LEFEBVRE, PJ ;

LUYCKX, AS .

ARCHIVES INTERNATIONALES DE PHYSIOLOGIE ET DE BIOCHIMIE, 1966, 74 (05) :867-&

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