EFFECT OF INDOMETHACIN AND ASA ON INVIVO INDUCED WHITE PLATELET ARTERIAL THROMBUS FORMATION

被引：24

作者：

BOURGAIN, RH

机构：

[1] Laboratory of Physiology, Physiopathology Free University of Brussels (V.U.B.) Eversstr. 2 -

来源：

THROMBOSIS RESEARCH | 1978年 / 12卷 / 06期

关键词：

D O I：

10.1016/0049-3848(78)90063-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

White platelet thrombus formation in a branch of the mesenteric artery of the rat induced by electrical current application followed by ADP superfusion can be inhibited by Aspirin and indomethacin topically applied. This phenomenon could result from the decrease of the cyclooxygenase-like activity present in the vascular wall structures. © 1978.

引用

收藏

页码：1079 / 1086

页数：8

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[1] PROSTACYCLIN INCREASES CYCLIC-AMP LEVELS AND ADENYLATE-CYCLASE ACTIVITY IN PLATELETS [J].

BEST, LC ;

MARTIN, TJ ;

RUSSELL, RGG ;

PRESTON, FE .

NATURE, 1977, 267 (5614) :850-851

[2] EFFECT OF DEFIBRASE ON ARTERIAL THROMBUS FORMATION [J].

BOURGAIN, RH ;

SIX, F .

THROMBOSIS RESEARCH, 1975, 6 (02) :195-200

[3] CONTINUOUS REGISTRATION METHOD IN EXPERIMENTAL ARTERIAL THROMBOSIS IN RAT [J].

BOURGAIN, RH ;

SIX, F .

THROMBOSIS RESEARCH, 1974, 4 (04) :599-607

[4]

BOURGAIN RH, UNPUBLISHED

[5] ARTERIAL-WALLS GENERATE FROM PROSTAGLANDIN ENDOPEROXIDES A SUBSTANCE (PROSTAGLANDIN-X) WHICH RELAXES STRIPS OF MESENTERIC AND CELIAC ARTERIES AND INHIBITS PLATELET-AGGREGATION [J].

BUNTING, S ;

GRYGLEWSKI, R ;

MONCADA, S ;

VANE, JR .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1976, 12 (06) :897-913

[6] ENZYME ISOLATED FROM ARTERIES TRANSFORMS PROSTAGLANDIN ENDOPEROXIDES TO AN UNSTABLE SUBSTANCE THAT INHIBITS PLATELET-AGGREGATION [J].

MONCADA, S ;

GRYGLEWSKI, R ;

BUNTING, S ;

VANE, JR .

NATURE, 1976, 263 (5579) :663-665

[7] DIFFERENTIAL FORMATION OF PROSTACYCLIN (PGX OR PGI2) BY LAYERS OF ARTERIAL-WALL - EXPLANATION FOR ANTI-THROMBOTIC PROPERTIES OF VASCULAR ENDOTHELIUM [J].

MONCADA, S ;

HERMAN, AG ;

HIGGS, EA ;

VANE, JR .

THROMBOSIS RESEARCH, 1977, 11 (03) :323-344

[8] LIPID PEROXIDE INHIBITS ENZYME IN BLOOD-VESSEL MICROSOMES THAT GENERATES FROM PROSTAGLANDIN ENDOPEROXIDES SUBSTANCE (PROSTAGLANDIN-X) WHICH PREVENTS PLATELET-AGGREGATION [J].

MONCADA, S ;

GRYGLEWSKI, RJ ;

BUNTING, S ;

VANE, JR .

PROSTAGLANDINS, 1976, 12 (05) :715-737

[9] NORMAL PROSTACYCLIN-LIKE ACTIVITY IN VASCULAR TISSUES FROM THROMBOCYTOPENIC RATS [J].

VILLA, S ;

CALLIONI, A ;

GAETANO, GD .

THROMBOSIS RESEARCH, 1977, 11 (06) :701-704

[10] SYNTHESIS OF PROSTAGLANDIN-I2 (PROSTACYCLIN) BY CULTURED HUMAN AND BOVINE ENDOTHELIAL CELLS - (PROSTAGLANDIN-X INHIBITION OF PLATELET AGGREGATION THROMBOGENESIS) [J].

WEKSLER, BB ;

MARCUS, AJ ;

JAFFE, EA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (09) :3922-3926