SELECTIVE NEUROTOXIC ACTION OF CAPSAICIN ON GLOMERULAR C-TYPE TERMINALS IN RAT SUBSTANTIA GELATINOSA

被引：47

作者：

PALERMO, NN

BROWN, HK

SMITH, DL

机构：

[1] UNIV S FLORIDA, COLL MED, DEPT PHARMACOL & THERAPEUT, TAMPA, FL 33612 USA

[2] UNIV S FLORIDA, COLL MED, DEPT ANAT, TAMPA, FL 33612 USA

来源：

BRAIN RESEARCH | 1981年 / 208卷 / 02期

关键词：

D O I：

10.1016/0006-8993(81)90585-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Capsaicin exerts a selective neurotoxic action to induce degeneration of glomerular C-type nerve terminals in adult rats. Since the C terminals may be essential components of the circuitry for modulation of pain, it is suggested that capsaicin induced analgesia is the result of this neurotoxic action.

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收藏

页码：506 / 510

页数：5

相关论文

共 18 条

[1] SUBSTANTIA GELATINOSA ROLANDI OF RAT - FINE-STRUCTURE, CYTOCHEMISTRY (ACID-PHOSPHATASE) AND CHANGES AFTER DORSAL ROOT SECTION [J].

COIMBRA, A ;

SODREBOR.BP ;

MAGALHAES, MM .

JOURNAL OF NEUROCYTOLOGY, 1974, 3 (02) :199-217

[2]

D'amour FE, 1941, J PHARMACOL EXP THER, V72, P74

[3] SYNAPTIC ORGANIZATION OF SUBSTANTIA GELATINOSA GLOMERULI IN SPINAL TRIGEMINAL NUCLEUS OF ADULT CAT [J].

GOBEL, S .

JOURNAL OF NEUROCYTOLOGY, 1974, 3 (02) :219-243

[4]

GOBEL S, 1976, ADV PAIN RES THER, V1, P165

[5] NOCICEPTIVE THRESHOLD AFTER NEONATAL CAPSAICIN TREATMENT [J].

HOLZER, P ;

JURNA, I ;

GAMSE, R ;

LEMBECK, F .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1979, 58 (04) :511-514

[6] PHARMACOLOGICALLY INDUCED SELECTIVE DEGENERATION OF CHEMOSENSITIVE PRIMARY SENSORY NEURONS [J].

JANCSO, G ;

KIRALY, E ;

JANCSOGABOR, A .

NATURE, 1977, 270 (5639) :741-743

[7] DIRECT EVIDENCE FOR NEUROGENIC INFLAMMATION AND ITS PREVENTION BY DENERVATION AND BY PRETREATMENT WITH CAPSAICIN [J].

JANCSO, N ;

JANCSOGA.A ;

SZOLCSANYI, J .

BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1967, 31 (01) :138-+

[8] CAPSAICIN-INDUCED DEPLETION OF SUBSTANCE-P FROM PRIMARY SENSORY NEURONS [J].

JESSELL, TM ;

IVERSEN, LL ;

CUELLO, AC .

BRAIN RESEARCH, 1978, 152 (01) :183-188

[9] MITOCHONDRIAL ALTERATIONS IN SPINAL GANGLION CELLS OF RAT ACCOMPANYING LONG-LASTING SENSORY DISTURBANCE INDUCED BY CAPSAICIN [J].

JOO, F ;

SZOLCSANYI, J ;

JANCSOGA.A .

LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY, 1969, 8 (11P1) :621-+

[10] NEUROANATOMICAL SUBSTRATES OF NOCICEPTION IN SPINAL-CORD [J].

KERR, FWL .

PAIN, 1975, 1 (04) :325-356