PERTURBATIONS IN THE MODEL OF ESTROGEN-RECEPTOR REGULATION OF GENE-EXPRESSION

被引：52

作者：

GORSKI, J ^{[1
]}

FURLOW, JD ^{[1
]}

MURDOCH, FE ^{[1
]}

FRITSCH, M ^{[1
]}

KANEKO, K ^{[1
]}

YING, CW ^{[1
]}

MALAYER, JR ^{[1
]}

机构：

[1] UNIV WISCONSIN,DEPT ANIM SCI,MADISON,WI 53706

来源：

BIOLOGY OF REPRODUCTION | 1993年 / 48卷 / 01期

关键词：

D O I：

10.1095/biolreprod48.1.8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Estrogen receptors are key elements in the mechanisms of action of estrogenic hormones. Models of how estrogens and their receptors interact and subsequently modify gene expression should be reevaluated to explain new data currently available. The following review discusses nuclear localization, DNA binding, and protein structural changes of the estrogen receptor induced by estrogen binding. We also discuss how these phenomena relate to the induction of changes in gene expression.

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页码：8 / 14

页数：7

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