CNS EFFECTS OF THE ANTIHISTAMINES DIPHENHYDRAMINE AND TERFENADINE (RMI 9918)

被引：58

作者：

FINK, M ^{[1
]}

IRWIN, P ^{[1
]}

机构：

[1] LONG ISL RES INST,CENT ISLIP,NY

来源：

PHARMAKOPSYCHIATRIE NEURO-PSYCHOPHARMAKOLOGIE | 1979年 / 12卷 / 01期

关键词：

D O I：

10.1055/s-0028-1094592

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The quantitative EEG profile of a putative antihistaminic drug, terfenadine, was determined in a crossover comparison with diphenhydramine in normal male volunteers. Terfenadine failed to elicit the characteristic EEG or behavioral effects of sedative anti-histaminics, and was distinguishable from diphenhydramine. The EEG profile confirmed the lack of CNS effect observed in preclinical and clinical trials.

引用

页码：35 / 44

页数：10

共 25 条

[1] EEG FINDINGS FOLLOWING INTRAVENOUS INJECTION OF DIPHENHYDRAMINE HYDROCHLORIDE (BENADRYL) [J].