RELATED TARGET ENHANCERS FOR DORSAL AND NF-KAPPA-B SIGNALING PATHWAYS

被引：31

作者：

GONZALEZCRESPO, S ^{[1
]}

LEVINE, M ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,CTR MOLEC GENET,DEPT BIOL,LA JOLLA,CA 92093

来源：

SCIENCE | 1994年 / 264卷 / 5156期

关键词：

D O I：

10.1126/science.8146656

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Drosophila dorsoventral (DV) patterning and mammalian hematopoiesis are regulated by related signaling pathways (Toll, interleukin-1) and transcription factors (dorsal, nuclear factor-kappaB). These factors interact with related enhancers, such as the rhomboid NEE and kappa light chain enhancer, that contain similar arrangements of activator and repressor binding sites. It is shown that the kappa enhancer can generate lateral stripes of gene expression in transgenic Drosophila embryos in a pattern similar to that directed by the rhomboid NEE. Drosophila DV determinants direct these stripes through the corresponding mammalian cis regulatory elements in the kappa enhancer, including the kappaB site and kappaE boxes. These results suggest that enhancers can couple conserved signaling pathways to divergent gene functions.

引用

页码：255 / 258

页数：4

共 48 条

[1] A DROSOPHILA CREB ATF TRANSCRIPTIONAL ACTIVATOR BINDS TO BOTH FAT BODY-SPECIFIC AND LIVER-SPECIFIC REGULATORY ELEMENTS [J].

ABEL, T ;

BHATT, R ;

MANIATIS, T .

GENES & DEVELOPMENT, 1992, 6 (03) :466-480

[2] CLONING OF A MITOGEN-INDUCIBLE GENE ENCODING A KAPPA-B DNA-BINDING PROTEIN WITH HOMOLOGY TO THE REL ONCOGENE AND TO CELL-CYCLE MOTIFS [J].

BOURS, V ;

VILLALOBOS, J ;

BURD, PR ;

KELLY, K ;

SIEBENLIST, U .

NATURE, 1990, 348 (6296) :76-80

[3] THE EXPRESSION OF 3 MEMBERS OF THE ACHAETE-SCUTE GENE-COMPLEX CORRELATES WITH NEUROBLAST SEGREGATION IN DROSOPHILA [J].

CABRERA, CV ;

MARTINEZARIAS, A ;

BATE, M .

CELL, 1987, 50 (03) :425-433

[4] MOLECULAR GENETICS OF THE ACHAETE-SCUTE GENE-COMPLEX OF DROSOPHILA-MELANOGASTER [J].

CAMPUZANO, S ;

CARRAMOLINO, L ;

CABRERA, CV ;

RUIZGOMEZ, M ;

VILLARES, R ;

BORONAT, A ;

MODOLELL, J .

CELL, 1985, 40 (02) :327-338

[5] DAUGHTERLESS, A DROSOPHILA GENE ESSENTIAL FOR BOTH NEUROGENESIS AND SEX DETERMINATION, HAS SEQUENCE SIMILARITIES TO MYC AND THE ACHAETE-SCUTE COMPLEX [J].

CAUDY, M ;

VASSIN, H ;

BRAND, M ;

TUMA, R ;

JAN, LY ;

JAN, YN .

CELL, 1988, 55 (06) :1061-1067

[6] MOLECULAR CHARACTERIZATION OF DAUGHTERLESS, A DROSOPHILA SEX DETERMINATION GENE WITH MULTIPLE ROLES IN DEVELOPMENT [J].

CRONMILLER, C ;

SCHEDL, P ;

CLINE, TW .

GENES & DEVELOPMENT, 1988, 2 (12A) :1666-1676

[7] THE DAUGHTERLESS GENE-PRODUCT IN DROSOPHILA IS A NUCLEAR-PROTEIN THAT IS BROADLY EXPRESSED THROUGHOUT THE ORGANISM DURING DEVELOPMENT [J].

CRONMILLER, C ;

CUMMINGS, CA .

MECHANISMS OF DEVELOPMENT, 1993, 42 (03) :159-169

[8] THE NF-KAPPA-B AND SP1 MOTIFS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 LONG TERMINAL REPEAT FUNCTION AS NOVEL THYROID-HORMONE RESPONSE ELEMENTS [J].

DESAIYAJNIK, V ;

SAMUELS, HH .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (08) :5057-5069

[9] A CONSERVED REGULATORY UNIT IMPLICATED IN TISSUE-SPECIFIC GENE-EXPRESSION IN DROSOPHILA AND MAN [J].

FALB, D ;

MANIATIS, T .

GENES & DEVELOPMENT, 1992, 6 (03) :454-465

[10] CACTUS, A GENE INVOLVED IN DORSOVENTRAL PATTERN-FORMATION OF DROSOPHILA, IS RELATED TO THE I-KAPPA-B GENE FAMILY OF VERTEBRATES [J].

GEISLER, R ;

BERGMANN, A ;

HIROMI, Y ;

NUSSLEINVOLHARD, C .

CELL, 1992, 71 (04) :613-621

← 1 2 3 4 5 →