INDUCTION OF PLASMINOGEN ACTIVATOR BY ESTROGEN IN A HUMAN-BREAST CANCER CELL-LINE (MCF-7)

被引：143

作者：

BUTLER, WB ^{[1
]}

KIRKLAND, WL ^{[1
]}

JORGENSEN, TL ^{[1
]}

机构：

[1] MICHIGAN CANC FDN, DEPT BIOL, DETROIT, MI 48201 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 04期

关键词：

D O I：

10.1016/0006-291X(79)91181-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human breast cancer cell line (MCF-7) produces a plasminogen activator. Under conditions where the growth of these cells is neither dependent on nor stimulated by estradiol as little as 10-10M estradiol stimulates plasminogen activator production. This stimulation is prevented by actinomycin D or cycloheximide, indicating that it probably requires new RNA and protein synthesis. Stimulation is also inhibited by the antiestrogen tamoxifen but this inhibition can be overcome by higher levels of estradiol. © 1979.

引用

页码：1328 / 1334

页数：7

共 19 条

[1]

BARRETT JC, 1977, CANCER RES, V37, P1182

[2]

CLIFFTON EE, 1955, CANCER, V8, P1146, DOI 10.1002/1097-0142(1955)8:6<1146::AID-CNCR2820080610>3.0.CO

[3]

2-W

[4]

HIGUCHI K, 1973, IN VITRO CELL DEV B, V9, P114