ANTIGEN-SPECIFICITY OF GAMMA-DELTA LYMPHOCYTES-T

被引：55

作者：

BORN, WK

OBRIEN, RL

MODLIN, RL

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90024

[2] UNIV COLORADO,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,DENVER,CO 80262

[3] UNIV CALIF LOS ANGELES,SCH MED,DIV DERMATOL,LOS ANGELES,CA 90024

来源：

FASEB JOURNAL | 1991年 / 5卷 / 12期

关键词：

GAMMA-DELTA T-CELLS; INFECTION; SPECIFICITY; FUNCTION;

D O I：

10.1096/fasebj.5.12.1717333

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gamma-delta-T cells represent a new lymphocyte subset without a definitive functional assignment. Although in many ways similar to alpha-beta-T lymphocytes, they are clearly distinguished by their expression of a different set of T cell receptor genes, a different distribution in normal tissues, and perhaps also different ligand specificities. Because gamma-delta-T cells appear to be involved in a variety of human diseases, the determination of their biological role has become an important challenge for immunologists and researchers in related areas.

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页码：2699 / 2705

页数：7

相关论文

共 92 条

[1] INDUCTION OF HUMAN TCR-GAMMA-DELTA+ AND TCR-GAMMA-DELTA-CD2+CD3- DOUBLE NEGATIVE LYMPHOCYTES BY BACTERIAL STIMULATION [J].

ABO, T ;

SUGAWARA, S ;

SEKI, S ;

FUJII, M ;

RIKIISHI, H ;

TAKEDA, K ;

KUMAGAI, K .

INTERNATIONAL IMMUNOLOGY, 1990, 2 (08) :775-785

[2] LIMITED DIVERSITY OF GAMMA-DELTA-ANTIGEN RECEPTOR GENES OF THY-1+ DENDRITIC EPIDERMAL-CELLS [J].

ASARNOW, DM ;

KUZIEL, WA ;

BONYHADI, M ;

TIGELAAR, RE ;

TUCKER, PW ;

ALLISON, JP .

CELL, 1988, 55 (05) :837-847

[3] RESIDENT PULMONARY LYMPHOCYTES EXPRESSING THE GAMMA-DELTA T-CELL RECEPTOR [J].

AUGUSTIN, A ;

KUBO, RT ;

SIM, GK .

NATURE, 1989, 340 (6230) :239-241

[4]

AUTRAN B, 1989, CLIN EXP IMMUNOL, V75, P206

[5] INCREASED NUMBERS OF LYMPHOCYTE-T WITH GAMMA-DELTA-POSITIVE ANTIGEN RECEPTORS IN A SUBGROUP OF INDIVIDUALS WITH PULMONARY SARCOIDOSIS [J].

BALBI, B ;

MOLLER, DR ;

KIRBY, M ;

HOLROYD, KJ ;

CRYSTAL, RG .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (05) :1353-1361

[6] EXTRATHYMIC ORIGIN OF INTESTINAL INTRAEPITHELIAL LYMPHOCYTES BEARING T-CELL ANTIGEN RECEPTOR-GAMMA-DELTA [J].

BANDEIRA, A ;

ITOHARA, S ;

BONNEVILLE, M ;

BURLENDEFRANOUX, O ;

MOTASANTOS, T ;

COUTINHO, A ;

TONEGAWA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (01) :43-47

[7] STRUCTURE AND SPECIFICITY OF T-CELL RECEPTOR-GAMMA RECEPTOR-DELTA ON MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN-SPECIFIC CD3+, CD4-, CD8- LYMPHOCYTES-T [J].

BLUESTONE, JA ;

CRON, RQ ;

COTTERMAN, M ;

HOULDEN, BA ;

MATIS, LA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (05) :1899-1916

[8] RECOGNITION OF A SELF MAJOR HISTOCOMPATIBILITY COMPLEX TL REGION PRODUCT BY GAMMA-DELTA T-CELL RECEPTORS [J].

BONNEVILLE, M ;

ITO, K ;

KRECKO, EG ;

ITOHARA, S ;

KAPPES, D ;

ISHIDA, I ;

KANAGAWA, O ;

JANEWAY, CA ;

MURPHY, DB ;

TONEGAWA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) :5928-5932

[9] INTESTINAL INTRAEPITHELIAL LYMPHOCYTES ARE A DISTINCT SET OF GAMMA-DELTA-T-CELLS [J].

BONNEVILLE, M ;

JANEWAY, CA ;

ITO, K ;

HASER, W ;

ISHIDA, I ;

NAKANISHI, N ;

TONEGAWA, S .

NATURE, 1988, 336 (6198) :479-481

[10]

BORN W, 1990, IMMUNOL TODAY, V11, P40

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