CARBOXYL-TERMINAL HEPARIN-BINDING FRAGMENTS OF PLATELET FACTOR-IV RETAIN THE BLOCKING EFFECT ON THE RECEPTOR-BINDING OF BASIC FIBROBLAST GROWTH-FACTOR

被引：20

作者：

SATO, Y

WAKI, M

OHNO, M

KUWANO, M

SAKATA, T

机构：

[1] OITA MED UNIV,DEPT BIOCHEM,HASAMA MACHI,OITA 87955,JAPAN

[2] KYUSHU UNIV,FAC SCI,DEPT CHEM,BIOCHEM LAB,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1993年 / 84卷 / 05期

关键词：

PLATELET FACTOR-IV; HEPARIN-BINDING DOMAIN; BASIC FIBROBLAST GROWTH FACTOR; RECEPTOR BINDING;

D O I：

10.1111/j.1349-7006.1993.tb00163.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Platelet factor 4 (PF-4) blocks the binding of basic fibroblast growth factor (bFGF) to its receptor. In the present study, we constructed carboxyl-terminal fragments, which represent the heparin-binding region of the PF-4 molecule, and examined whether these synthetic peptides retain the blocking effects on the receptor binding of bFGF. Synthetic peptides inhibited the receptor binding of bFGF. Furthermore, they inhibited the migration and tube formation of bovine capillary endothelial cells in culture (these phenomena are dependent on endogenous bFGF).

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收藏

页码：485 / 488

页数：4

相关论文

共 14 条

[1] INHIBITION OF HUMAN MEGAKARYOCYTOPOIESIS INVITRO BY PLATELET FACTOR-4 (PF4) AND A SYNTHETIC COOH-TERMINAL PF4 PEPTIDE [J].

GEWIRTZ, AM ;

CALABRETTA, B ;

RUCINSKI, B ;

NIEWIAROWSKI, S ;

XU, WY .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (05) :1477-1486

[2] PLATELET FACTOR-4 REGULATES OSTEOCLASTIC BONE-RESORPTION INVITRO [J].

HORTON, JE ;

HARPER, J ;

HARPER, E .

BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 630 (03) :459-462

[3] INHIBITION OF ANGIOGENESIS BY RECOMBINANT HUMAN-PLATELET FACTOR-IV AND RELATED PEPTIDES [J].

MAIONE, TE ;

GRAY, GS ;

PETRO, J ;

HUNT, AJ ;

DONNER, AL ;

BAUER, SI ;

CARSON, HF ;

SHARPE, RJ .

SCIENCE, 1990, 247 (4938) :77-79

[4] TRANSFORMING GROWTH FACTOR-BETA-1 IS A HEPARIN-BINDING PROTEIN - IDENTIFICATION OF PUTATIVE HEPARIN-BINDING REGIONS AND ISOLATION OF HEPARINS WITH VARYING AFFINITY FOR TGF-BETA-1 [J].

MCCAFFREY, TA ;

FALCONE, DJ ;

DU, BH .

JOURNAL OF CELLULAR PHYSIOLOGY, 1992, 152 (02) :430-440

[5]

MEIENHOFER J, 1979, INT J PEPT PROT RES, V13, P35

[6] HIGH AND LOW AFFINITY BINDING-SITES FOR BASIC FIBROBLAST GROWTH-FACTOR ON CULTURED-CELLS - ABSENCE OF A ROLE FOR LOW AFFINITY BINDING IN THE STIMULATION OF PLASMINOGEN-ACTIVATOR PRODUCTION BY BOVINE CAPILLARY ENDOTHELIAL-CELLS [J].

MOSCATELLI, D .

JOURNAL OF CELLULAR PHYSIOLOGY, 1987, 131 (01) :123-130

[7] REQUIREMENT OF HEPARAN-SULFATE FOR BFGF-MEDIATED FIBROBLAST GROWTH AND MYOBLAST DIFFERENTIATION [J].

RAPRAEGER, AC ;

KRUFKA, A ;

OLWIN, BB .

SCIENCE, 1991, 252 (5013) :1705-1708

[8] RECENT DEVELOPMENTS IN THE CELL BIOLOGY OF BASIC FIBROBLAST GROWTH-FACTOR [J].

RIFKIN, DB ;

MOSCATELLI, D .

JOURNAL OF CELL BIOLOGY, 1989, 109 (01) :1-6

[9] AUTOCRINE ACTIVITIES OF BASIC FIBROBLAST GROWTH-FACTOR - REGULATION OF ENDOTHELIAL-CELL MOVEMENT, PLASMINOGEN-ACTIVATOR SYNTHESIS, AND DNA-SYNTHESIS [J].

SATO, Y ;

RIFKIN, DB .

JOURNAL OF CELL BIOLOGY, 1988, 107 (03) :1199-1205

[10] AUTOCRINOLOGICAL ROLE OF BASIC FIBROBLAST GROWTH-FACTOR ON TUBE FORMATION OF VASCULAR ENDOTHELIAL-CELLS INVITRO [J].

SATO, Y ;

SHIMADA, T ;

TAKAKI, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 180 (02) :1098-1102