PARAMYOSIN IS THE SCHISTOSOMA-MANSONI (TREMATODA) HOMOLOG OF ANTIGEN-B FROM TAENIA-SOLIUM (CESTODA)

被引:72
作者
LACLETTE, JP
LANDA, A
ARCOS, L
WILLMS, K
DAVIS, AE
SHOEMAKER, CB
机构
[1] NATL AUTONOMOUS UNIV MEXICO,INST INVEST BIOMED,DEPT IMMUNOL,MEXICO CITY 04510,DF,MEXICO
[2] CHILDRENS HOSP MED CTR,DIV IMMUNOL,BOSTON,MA 02115
基金
美国国家卫生研究院;
关键词
SCHISTOSOMA-MANSONI PARAMYOSIN; TAENIA-SOLIUM; ANTIGEN-B; CESTODA; TREMATODA; GENE CLONING AND EXPRESSION; DNA SEQUENCING;
D O I
10.1016/0166-6851(91)90015-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Antigen B, a major antigen of the cestode parasite Taenia solium, has been purified and a protion of amino acid sequence obtained. Paramyosin of the trematode parasite Schistosoma mansoni, an immunogenic protein that has shown promise as a vaccine candidate, has several biochemical and immunological properties in common with antigen B. A full-length cDNA clone of S. mansoni paramyosin has been obtained and the predicted translation product contains a sequence that is highly homologous to the sequence obtained for antigen B. The predicted amino acid composition and isolectric point of paramyosin are nearly identical to those established for antigen B. Recombinant S. mansoni paramyosin, expressed in Escherichia coli as a fusion protein with beta-galactosidase, was recognized by antisera against T. solium antigen B. We conclude from these results that S. mansoni paramyosin and T. solium antigen B are homologous proteins. Since S. mansoni paramyosin is thought to be a muscle protein and T. solium antigen B a secreted glycoprotein with anti-complement activity, this conclusion raises some interesting questions regarding the role of this class of proteins in the host-parasite relationship.
引用
收藏
页码:287 / 296
页数:10
相关论文
共 35 条
[1]   SCREENING GAMMAGT RECOMBINANT CLONES BY HYBRIDIZATION TO SINGLE PLAQUES INSITU [J].
BENTON, WD ;
DAVIS, RW .
SCIENCE, 1977, 196 (4286) :180-182
[2]   PARAMYOSIN AND FILAMENTS OF MOLLUSCAN CATCH MUSCLES .1. PARAMYOSIN - STRUCTURE AND ASSEMBLY [J].
COHEN, C ;
SZENTGYO.AG ;
KENDRICK.J .
JOURNAL OF MOLECULAR BIOLOGY, 1971, 56 (02) :223-+
[3]   A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].
FEINBERG, AP ;
VOGELSTEIN, B .
ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13
[4]   INDUCTION OF RESISTANCE TO SCHISTOSOMA-MANSONI INFECTION IN MICE BY PURIFIED PARASITE PARAMYOSIN [J].
FLANIGAN, TP ;
KING, CH ;
LETT, RR ;
NANDURI, J ;
MAHMOUD, AAF .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (03) :1010-1014
[5]  
FLISSER A, 1980, CLIN EXP IMMUNOL, V39, P27
[6]  
GIBSON TJ, 1984, THESIS U CAMBRIDGE C
[7]   A LAMBDA-GT11 CDNA RECOMBINANT THAT ENCODES DIROFILARIA-IMMITIS PARAMYOSIN [J].
GRANDEA, AG ;
TUYEN, LK ;
ASIKIN, N ;
DAVIS, TB ;
PHILIPP, M ;
COHEN, C ;
MCREYNOLDS, LA .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1989, 35 (01) :31-41
[8]   SCHISTOSOMA-MANSONI - STAGE-SPECIFIC EXPRESSION OF MUSCLE-SPECIFIC GENES [J].
GROSSMAN, Z ;
RAM, D ;
MARKOVICS, A ;
TARRABHAZDAI, R ;
LANTNER, F ;
ZIV, E ;
SCHECHTER, I .
EXPERIMENTAL PARASITOLOGY, 1990, 70 (01) :62-71
[9]  
Guerra G., 1982, P437
[10]   PARAMYOSIN GENE (UNC-15) OF CAENORHABDITIS-ELEGANS - MOLECULAR-CLONING, NUCLEOTIDE-SEQUENCE AND MODELS FOR THICK FILAMENT STRUCTURE [J].
KAGAWA, H ;
GENGYO, K ;
MCLACHLAN, AD ;
BRENNER, S ;
KARN, J .
JOURNAL OF MOLECULAR BIOLOGY, 1989, 207 (02) :311-333