HYPOBARIC HYPOXIA - EFFECTS ON EARLY DEVELOPMENT OF TRYPTOPHAN OXYGENASE IN NEONATAL RATS

被引：4

作者：

FRANCESCONI, RP

MAGER, M

机构：

[1] Biochemistry and Pharmacology Laboratory, U.S. Army Research Institute of Environmental Medicine, Natick

来源：

SCIENCE | 1969年 / 166卷 / 3911期

关键词：

D O I：

10.1126/science.166.3911.1412

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Despite a reduction in liver and body weights of neonatal rats born and reared at a simulated altitude of 5790 meters (oxygen pressure, 76.36 millimeters of mercury), the hepatic enzyme tryptophan oxygenase develops prematurely in these stressed animals as compared to controls reared at sea level. Also, the specific activities remain distinctly elevated through the first 9 days of age; thus, the competence for premature synthesis of tryptophan oxygenase is confirmed in neonatal rats.

引用

页码：1412 / +

页数：1

共 16 条

[1]

AUERBACH VH, 1959, J BIOL CHEM, V234, P304

[2] INFLUENCE OF HYPOXIA GLUCOCORTICOID AND ENDOTOXIN ON HEPATIC ENZYME INDUCTION [J].

BERRY, LJ ;

SMYTHE, DS ;

COLWELL, LS ;

CHU, PHC .

AMERICAN JOURNAL OF PHYSIOLOGY, 1968, 215 (03) :587-&

[3] EFFECT OF HYPOPHYSECTOMY AND GROWTH HORMONE ON INDUCTIONS OF RAT LIVER TYROSINE AMINOTRANSFERASE AND TRYPTOPHAN OXYGENASE BY HYDROCORTISONE [J].

CSANYI, V ;

GREENGARD, O .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1968, 125 (03) :824-+

[4] EFFECT OF DEVELOPMENT AND HYDROCORTISONE ON TRYPTOPHAN OXYGENASE FORMAMIDASE AND TYROSINE AMINOTRANSFERASE IN LIVERS OF YOUNG RATS [J].

FRANZ, JM ;

KNOX, WE .

BIOCHEMISTRY, 1967, 6 (11) :3464-+

[5]

GREENGAR.O, 1968, J BIOL CHEM, V243, P2745

[6] ENZYMIC DIFFERENTIATION IN MAMMALIAN LIVER [J].

GREENGARD, O .

SCIENCE, 1969, 163 (3870) :891-+

[7] CIRCADIAN OSCILLATION IN RAT LIVER TRYPTOPHAN PYRROLASE AND ITS ANALYSIS BY SUBSTRATE AND HORMONE INDUCTION [J].

HARDELAND, R ;

RENSING, L .

NATURE, 1968, 219 (5154) :619-+

[8] FACTORS AFFECTING PREMATURE INDUCTION OF TYROSINE AMINOTRANSFERASE IN FOETAL RAT LIVER [J].

HOLT, PG ;

OLIVER, IT .

BIOCHEMICAL JOURNAL, 1968, 108 (02) :333-&

[9]

KNOX W. EUGENE, 1955, JOUR BIOL CHEM, V214, P307

[10] EFFECT OF HIGH ALTITUDE ON LACTIC DEHYDROGENASE ISOZYMES OF NEONATAL AND ADULT RATS [J].

MAGER, M ;

BLATT, WF ;

NATALE, PJ ;

BLATTEIS, CM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1968, 215 (01) :8-&

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