The HA1 of cold-adapted influenza B vaccine is not altered during replication in human vaccinees

被引：3

作者：

Abbasi, S

Gruber, W

Edwards, K

Gubareva, L

Webster, RG

Kawaoka, Y

机构：

[1] ST JUDE CHILDRENS RES HOSP, DEPT VIROL & MOLEC BIOL, MEMPHIS, TN 38101 USA

[2] ST JUDE CHILDRENS RES HOSP, DEPT INFECT DIS, MEMPHIS, TN 38101 USA

[3] UNIV TENNESSEE, DEPT PEDIAT, MEMPHIS, TN 38103 USA

[4] LEBONHEUR CHILDRENS HOSP & MED CTR, MEMPHIS, TN 38103 USA

[5] VANDERBILT UNIV, SCH MED, DEPT PEDIAT INFECT DIS, NASHVILLE, TN 37232 USA

[6] UNIV TENNESSEE, DEPT PATHOL, MEMPHIS, TN 38103 USA

来源：

VIRUS RESEARCH | 1995年 / 39卷 / 2-3期

关键词：

cold-adapted influenza vaccine; hemagglutinin; genetic stability; host-cell selection;

D O I：

10.1016/0168-1702(95)00097-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Influenza viruses recovered from 14 children 2-10 days after vaccination with an egg-grown, cold-adapted influenza B vaccine (B/AA/1/86) were analyzed. Hemagglutination-inhibition (HI) assays using monoclonal antibodies did not detect antigenic differences between the vaccine strain and the viruses recovered from the vaccinees. Furthermore, nucleotide sequence analysis of the HA1 region did not reveal any changes compared to the sequence of the vaccine strain. These findings indicate that influenza B vaccine hemagglutinin is genetically stable during replication in human vaccinees.

引用

收藏

页码：377 / 383

页数：7

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