COXSACKIE-B VIRUS-INFECTION AND ONSET OF CHILDHOOD DIABETES

被引：217

作者：

CLEMENTS, GB ^{[1
]}

GALBRAITH, DN ^{[1
]}

TAYLOR, KW ^{[1
]}

机构：

[1] ROYAL LONDON HOSP,MED UNIT,LONDON E1 1BB,ENGLAND

来源：

LANCET | 1995年 / 346卷 / 8969期

关键词：

D O I：

10.1016/S0140-6736(95)91270-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Infection with Coxsackie B viruses has insulin-dependent diabetes mellitus. Nine samples (64%) taken from children at the onset of diabetes were positive for enterovirus RNA by PCR. All of the children were under age six, and five were under age three. By contrast, enterovirus sequences were detected in only two of 45 serum samples from appropriate comparison children (4%). Sequences from six of the positive patients showed strong homology with Coxsachie B3 and B4 viruses, and there were some common patterns among the sequences from infected diabetic children. This is evidence for a role for enteroviruses in childhood diabetes.

引用

页码：221 / 223

页数：3

共 10 条

[1] DETECTION OF ENTEROVIRUS-SPECIFIC RNA IN SERUM - THE RELATIONSHIP TO CHRONIC FATIGUE [J].