REGULATION OF N-REGION DIVERSITY IN ANTIGEN RECEPTORS THROUGH THYMOCYTE DIFFERENTIATION AND THYMUS ONTOGENY

被引：136

作者：

BOGUE, M ^{[1
]}

GILFILLAN, S ^{[1
]}

BENOIST, C ^{[1
]}

MATHIS, D ^{[1
]}

机构：

[1] INST CHIM BIOL,INSERM,U184,F-67085 STRASBOURG,FRANCE

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 22期

关键词：

LYMPHOCYTE-T MATURATION; T-CELL REPERTOIRE; T-CELL RECEPTOR; TERMINAL DEOXYNUCLEOTIDYLTRANSFERASE;

D O I：

10.1073/pnas.89.22.11011

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The random addition of "N nucleotides" by terminal deoxynucleotidyltransferase (TdT) is an important component of the diversity of T-cell receptor genes. We have investigated the expression of TdT during thymocyte differentiation and thymus ontogeny. TdT gene transcripts are confined to immature thymocytes of the cortex, being down-regulated concomitantly with recombination-activating gene transcripts after positive selection of mature medullary T cells. According to in situ hybridization, TdT RNA is absent from the neonatal thymus, but it appears 3 to 5 days after birth, just before the appearance of significant N-region diversity in T-cell receptor junctional sequences but clearly after the thymus attains competence at clonal deletion.

引用

页码：11011 / 11015

页数：5

共 49 条

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[2]

BANGS LA, 1991, J IMMUNOL, V146, P1996

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