CERAMIDE - AN ENDOGENOUS REGULATOR OF APOPTOSIS AND GROWTH SUPPRESSION

被引：180

作者：

PUSHKAREVA, M ^{[1
]}

OBEID, LM ^{[1
]}

HANNUN, YA ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 06期

关键词：

D O I：

10.1016/0167-5699(95)80184-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The action of several cytokines is mediated via activation of the sphingomyelin cycle of signal transduction. Ceramide, the product of this pathway, is emerging as an intracellular messenger that mediates effects on terminal differentiation, apoptosis and cell-cycle arrest. Here, Marina Pushkareva, Lina Obeid and Yusuf Hannun discuss the regulation and mechanism of-action of this stress-activated pathway.

引用

页码：294 / 297

页数：4

共 33 条

[1]

BALLOU LR, 1992, J BIOL CHEM, V267, P20044

[2]

BETTS JC, 1994, J BIOL CHEM, V269, P8455

[3] APOPTOTIC SIGNALING THROUGH CD95 (FAS/APO-1) ACTIVATES AN ACIDIC SPHINGOMYELINASE [J].