INSULIN-LIKE GROWTH-FACTORS AND THEIR RECEPTORS AS GROWTH-REGULATORS IN NORMAL PHYSIOLOGY AND PATHOLOGICAL STATES

被引：112

作者：

LEROITH, D

ADAMO, M

WERNER, H

ROBERTS, CT

机构：

[1] Diabetes Branch, NIDDK, National Institutes of Health, Bethesda

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1991年 / 2卷 / 04期

关键词：

D O I：

10.1016/1043-2760(91)90003-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulinlike growth factors (IGFs), their binding proteins, and receptors are expressed by many different tissues, suggesting that they may act as parts of an autocrine-paracrine system in addition to having a classic endocrine role. Since these growth factors are essential for the normal growth and development of the organism, their altered rate of production in a number of important disease states results in severe growth alterations. These include nutritional deprivation, growth hormone deficiency, diabetes, and malignancy.

引用

页码：134 / 139

页数：6

共 41 条

[1] INSULIN-LIKE GROWTH FACTOR-I MESSENGER RIBONUCLEIC-ACIDS WITH ALTERNATIVE 5'-UNTRANSLATED REGIONS ARE DIFFERENTIALLY EXPRESSED DURING DEVELOPMENT OF THE RAT [J].