ANTIPARKINSONIAN DRUGS - INHIBITION OF DOPAMINE UPTAKE IN CORPUS STRIATUM AS A POSSIBLE MECHANISM OF ACTION

被引：352

作者：

COYLE, JT

SNYDER, SH

机构：

[1] Departments of Pharmacology and Experimental Therapeutics and Psychiatry and the Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore

来源：

SCIENCE | 1969年 / 166卷 / 3907期

关键词：

D O I：

10.1126/science.166.3907.899

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A variety of antiparkinsonian drugs are potent, noncompetitive inhibitors of dopamine uptake into synaptosomes in homogenates of rat corpus striatum. Inhibition of dopamine uptake may potentiate the synaptic actions of dopamine in the striatum and could explain the antiparkinsonian effects of these drugs. This hypothesis accounts for several clinical features of Parkinson's disease and predicts compounds which may be new therapeutic agents.

引用

页码：899 / +

页数：1

共 29 条

[1] RELATIONSHIP BETWEEN ANTI-ACETYLCHOLINE AND ANTI-TREMORINE ACTIVITY IN ANTI-PARKINSONIAN AND RELATED DRUGS [J].

AHMED, A ;

MARSHALL, PB .

BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1962, 18 (02) :247-&

[2]

AXELROD JULIUS, 1965, RECENT PROG HORMONE RES, V21, P597

[3]

BARBEAU A, 1969, 8 YEARS LDOPA THERAP

[4]

BOGDANSK.DF, 1967, PHARMACOLOGIST, V9, P250

[5]

BUNNEY WE, 1965, ARCH GEN PSYCHIAT, V13, P483

[6] SYMPATHETIC POSTGANGLIONIC MECHANISM [J].

BURN, JH ;

RAND, MJ .

NATURE, 1959, 184 (4681) :163-165

[7] MODIFICATION OF PARKINSONISM - CHRONIC TREATMENT WITH L-DOPA [J].

COTZIAS, GC ;

PAPAVASI.PS ;

GELLENE, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1969, 280 (07) :337-&

[8]

COYLE JT, IN PRESS

[9]

DAPRADA M, 1966, EXPERIENTIA, V22, P465

[10]

DAVIS JM, 1967, PHARMACOLOGIST, V9, P184

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