HIV WITH REDUCED SENSITIVITY TO ZIDOVUDINE (AZT) ISOLATED DURING PROLONGED THERAPY

被引：1580

作者：

LARDER, BA

DARBY, G

RICHMAN, DD

机构：

[1] UNIV CALIF SAN DIEGO,DEPT PATHOL,SAN DIEGO,CA 92103

[2] UNIV CALIF SAN DIEGO,DEPT MED,SAN DIEGO,CA 92103

[3] VET ADM MED CTR,SAN DIEGO,CA 92161

来源：

SCIENCE | 1989年 / 243卷 / 4899期

关键词：

D O I：

10.1126/science.2467383

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：1731 / 1734

页数：4

共 22 条

[1]

BURNS WH, 1982, LANCET, V1, P421

[2] DEVELOPMENT OF A SENSITIVE QUANTITATIVE FOCAL ASSAY FOR HUMAN IMMUNODEFICIENCY VIRUS INFECTIVITY [J].

CHESEBRO, B ;

WEHRLY, K .

JOURNAL OF VIROLOGY, 1988, 62 (10) :3779-3788

[3] ALTERED SUBSTRATE-SPECIFICITY OF HERPES-SIMPLEX VIRUS THYMIDINE KINASE CONFERS ACYCLOVIR-RESISTANCE [J].

DARBY, G ;

FIELD, HJ ;

SALISBURY, SA .

NATURE, 1981, 289 (5793) :81-83

[4] PATHOGENICITY IN MICE OF STRAINS OF HERPES-SIMPLEX VIRUS WHICH ARE RESISTANT TO ACYCLOVIR INVITRO AND INVIVO [J].

FIELD, HJ ;

DARBY, G .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1980, 17 (02) :209-216

[5] THE EFFICACY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

FISCHL, MA ;

RICHMAN, DD ;

GRIECO, MH ;

GOTTLIEB, MS ;

VOLBERDING, PA ;

LASKIN, OL ;

LEEDOM, JM ;

GROOPMAN, JE ;

MILDVAN, D ;

SCHOOLEY, RT ;

JACKSON, GG ;

DURACK, DT ;

KING, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) :185-191

[6]

HAERTLE T, 1988, J BIOL CHEM, V263, P5870

[7] ACYCLOVIR PROPHYLAXIS AGAINST HERPES-VIRUS INFECTIONS IN SEVERELY IMMUNOCOMPROMISED PATIENTS - RANDOMIZED DOUBLE-BLIND TRIAL [J].

HANN, IM ;

PRENTICE, HG ;

BLACKLOCK, HA ;

ROSS, MGR ;

BRIGDEN, D ;

ROSLING, AE ;

BURKE, C ;

CRAWFORD, DH ;

BRUMFITT, W ;

HOFFBRAND, AV .

BMJ-BRITISH MEDICAL JOURNAL, 1983, 287 (6389) :384-388

[8] INFECTION OF HTLV-III/LAV IN HTLV-I-CARRYING CELLS MT-2 AND MT-4 AND APPLICATION IN A PLAQUE-ASSAY [J].

HARADA, S ;

KOYANAGI, Y ;

YAMAMOTO, N .

SCIENCE, 1985, 229 (4713) :563-566

[9] HUMAN IMMUNODEFICIENCY VIRUS (HIV) ANTIGENEMIA (P24) IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) AND THE EFFECT OF TREATMENT WITH ZIDOVUDINE (AZT) [J].

JACKSON, GG ;

PAUL, DA ;

FALK, LA ;

RUBENIS, M ;

DESPOTES, JC ;

MACK, D ;

KNIGGE, M ;

EMESON, EE .

ANNALS OF INTERNAL MEDICINE, 1988, 108 (02) :175-180

[10]

KECKER RW, 1987, CLIN PHARMACOL THER, V41, P407

← 1 2 3 →