CA2+-INDUCED CA2+ RELEASE IN INSULIN-SECRETING CELLS

被引：81

作者：

ISLAM, MS

RORSMAN, P

BERGGREN, PO

机构：

[1] KAROLINSKA INST, KAROLINSKA HOSP,DEPT ENDOCRINOL, ROLF LUFT CTR DIABET RES,BOX 60500, S-10401 STOCKHOLM 60, SWEDEN

[2] GOTHENBURG UNIV, DEPT MED PHYS, S-40033 GOTHENBURG, SWEDEN

来源：

FEBS LETTERS | 1992年 / 296卷 / 03期

关键词：

CA2+-INDUCED CA2+ RELEASE; SULFHYDRYL REAGENT; THIMEROSAL; INTRACELLULAR CA2+ TRANSPORT; INSULIN-SECRETING CELL; PERMEABILIZED CELL;

D O I：

10.1016/0014-5793(92)80306-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sulphydryl reagent thimerosal (50-mu-M) released Ca2+ from a non-mitochondrial intracellular Ca2+ pool in a dose-dependent manner in permeabilized insulin-secreting RINm5F cells. This release was reversed after addition of the reducing agent dithiothreitol. Ca2+ was released from an Ins(1,4,5)P3-insensitive pool, since release was observed even after depletion of the Ins(1,4,5)P3-sensitive pool by a supramaximal dose of Ins(2,4,5)P3 or thapsigargin. The Ins(1,4,5)P3-sensitive pool remained essentially unaltered by thimerosal. Thimerosal-induced Ca2+ release was potentiated by caffeine. These findings suggest the existence of Ca2+ -induced Ca2+ release also in insulin-secreting cells.

引用

页码：287 / 291

页数：5

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