MONOPHOSPHORYL LIPID-A PROTECTS AGAINST GRAM-POSITIVE SEPSIS AND TUMOR-NECROSIS-FACTOR

被引：22

作者：

ASTIZ, ME ^{[1
]}

GALERA, A ^{[1
]}

SAHA, DC ^{[1
]}

CARPATI, C ^{[1
]}

RACKOW, EC ^{[1
]}

机构：

[1] NEW YORK MED COLL,VALHALLA,NY

来源：

SHOCK | 1994年 / 2卷 / 04期

关键词：

D O I：

10.1097/00024382-199410000-00007

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Monophosphoryl lipid A (MPL) is a less toxic derivative of lipid A that enhances survival from endotoxemia. This study examined whether MPL induced resistance to Gram-positive sepsis and cytokines. Mice were administered MPL or saline (phosphate-buffered saline) and challenged 24 h later with live Staphylococcus aureus (SA), staphylococcus enterotoxin B (SEB), toxic shock syndrome toxin (TSST-1), and tumor necrosis factor (TNF). Survival was determined at 72 h. A separate set of animals was phlebotomized for determination of cytokines. MPL increased survival from S. aureus bacteremia from 20 to 87% (p < .05). Interleukin-6 (IL-6) and interleukin-1 (IL-1) and TNF were also significantly decreased. SEB and TSST survival were enhanced from 10 to 90% (p < .05). In SEB-treated animals, TNF and IL-6 levels were significantly decreased. Survival from TNF infusion was increased from 20 to 100% with MPL, however, no significant differences in cytokines were observed. These data suggest that MPL induces resistance to Gram-positive sepsis and cytokine-mediated activity.

引用

页码：271 / 274

页数：4

共 35 条

[1] TREATMENT WITH RECOMBINANT HUMAN TUMOR-NECROSIS-FACTOR-ALPHA PROTECTS RATS AGAINST THE LETHALITY, HYPOTENSION, AND HYPOTHERMIA OF GRAM-NEGATIVE SEPSIS [J].