THE EFFECT OF LOCAL-ANESTHETICS ON ARTERIAL LIPID-METABOLISM - INHIBITION OF STEROL ESTERIFICATION INVITRO

被引：23

作者：

BELL, FP

机构：

来源：

ATHEROSCLEROSIS | 1981年 / 38卷 / 1-2期

关键词：

D O I：

10.1016/0021-9150(81)90106-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The local anesthetics lidocaine, tetracaine, benzocaine and dibucaine inhibit sterol esterification by acylCo[coenzyme]A:cholesterol acyltransferase (EC 2.3.1.26) in the microsomal fraction isolated from rabbit aortas. In arterial microsomes, the incorporation of [14C]oleoylCoA into [14C]steryl esters was inhibited in a dose-dependent way by the anesthetics over the concentration range 0.25-5.0 mM. The potency of inhibition was dibucaine > benzocaine > tetracaine > lidocaine > procaine with inhibition of .apprx. 85% occurring with 0.25 mM dibucaine. Sterol esterification to [14C]oleic acid was inhibited by the anesthetics in intact aortic tissue from the rabbit, dog and rat. A detailed study of the effects of 5 mM lidocaine on lipid biosynthesis in the rabbit aorta in vitro revealed that lidocaine inhibited sterol esterification to [14C]oleate and stimulated [14C]oleate incorporation into glycerides. [Arterial lipid relation to atherogenesis is discussed.].

引用

页码：81 / 88

页数：8

共 33 条

[1]

BELL FP, 1976, ARTERY, V2, P519

[2] EFFECT OF DIETARY DI-2-ETHYLHEXYL PHTHALATE ON LIPID BIOSYNTHESIS IN SELECTED TISSUES FROM RAT, INVITRO [J].