INFLUENCE OF PROLINE RESIDUES ON PROTEIN CONFORMATION

被引：1043

作者：

MACARTHUR, MW ^{[1
]}

THORNTON, JM ^{[1
]}

机构：

[1] UNIV LONDON BIRKBECK COLL,DEPT CRYSTALLOG,MOLEC BIOL LAB,LONDON WC1E 7HX,ENGLAND

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1991年 / 218卷 / 02期

关键词：

D O I：

10.1016/0022-2836(91)90721-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To study the influence of proline residues on three-dimensional structure, an analysis has been made of all proline residues and their local conformations extracted from the Brookhaven Protein Data bank. We have considered the conformation of the proline itself, the relative occurrence of cis and trans peptides preceding proline residues, the influence of proline on the conformation of the preceding residue and the conformations of various proline patterns (Pro-Pro, Pro-X-Pro, etc.). The results highlight the unique role of proline in determining local conformation. © 1991.

引用

页码：397 / 412

页数：16

共 32 条

[1]

Akrigg D., 1988, Nature, UK, V335, P745, DOI 10.1038/335745a0

[2] A NOVEL SUPERSECONDARY STRUCTURE IN GLOBULAR-PROTEINS COMPRISING THE COLLAGEN-LIKE HELIX AND BETA-TURN [J].

ANANTHANARAYANAN, VS ;

SOMAN, KV ;

RAMAKRISHNAN, C .

JOURNAL OF MOLECULAR BIOLOGY, 1987, 198 (04) :705-709

[3]

ARGOS P, 1982, INT J PEPT PROT RES, V19, P380

[4] HELIX GEOMETRY IN PROTEINS [J].

BARLOW, DJ ;

THORNTON, JM .

JOURNAL OF MOLECULAR BIOLOGY, 1988, 201 (03) :601-619

[5] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES [J].

BERNSTEIN, FC ;

KOETZLE, TF ;

WILLIAMS, GJB ;

MEYER, EF ;

BRICE, MD ;

RODGERS, JR ;

KENNARD, O ;

SHIMANOUCHI, T ;

TASUMI, M .

JOURNAL OF MOLECULAR BIOLOGY, 1977, 112 (03) :535-542

[6] HYPOTHESIS ABOUT THE FUNCTION OF MEMBRANE-BURIED PROLINE RESIDUES IN TRANSPORT PROTEINS [J].

BRANDL, CJ ;

DEBER, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (04) :917-921

[7] CONSIDERATION OF POSSIBILITY THAT SLOW STEP IN PROTEIN DENATURATION REACTIONS IS DUE TO CIS-TRANS ISOMERISM OF PROLINE RESIDUES [J].

BRANDTS, JF ;

HALVORSON, HR ;

BRENNAN, M .

BIOCHEMISTRY, 1975, 14 (22) :4953-4963

[8] ORTHOGONAL PACKING OF BETA-PLEATED SHEETS IN PROTEINS [J].

CHOTHIA, C ;

JANIN, J .

BIOCHEMISTRY, 1982, 21 (17) :3955-3965

[9] CONFORMATIONAL PARAMETERS FOR AMINO-ACIDS IN HELICAL, BETA-SHEET, AND RANDOM COIL REGIONS CALCULATED FROM PROTEINS [J].

CHOU, PY ;

FASMAN, GD .

BIOCHEMISTRY, 1974, 13 (02) :211-222

[10] STRUCTURE OF THE GENE ENCODING THE IMMUNODOMINANT SURFACE-ANTIGEN ON THE SPOROZOITE OF THE HUMAN MALARIA PARASITE PLASMODIUM-FALCIPARUM [J].

DAME, JB ;

WILLIAMS, JL ;

MCCUTCHAN, TF ;

WEBER, JL ;

WIRTZ, RA ;

HOCKMEYER, WT ;

MALOY, WL ;

HAYNES, JD ;

SCHNEIDER, I ;

ROBERTS, D ;

SANDERS, GS ;

REDDY, EP ;

DIGGS, CL ;

MILLER, LH .

SCIENCE, 1984, 225 (4662) :593-599

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