A SUPERANTIGEN ENCODED IN THE OPEN READING FRAME OF THE 3' LONG TERMINAL REPEAT OF MOUSE MAMMARY-TUMOR VIRUS

被引：407

作者：

CHOI, YW

KAPPLER, JW

MARRACK, P

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,DENVER,CO 80262

[2] UNIV COLORADO,HLTH SCI CTR,DEPT MED,DENVER,CO 80262

[3] UNIV COLORADO,HLTH SCI CTR,DEPT BIOCHEM BIOPHYS & GENET,DENVER,CO 80262

来源：

NATURE | 1991年 / 350卷 / 6315期

关键词：

D O I：

10.1038/350203a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mice express a collection of superantigens, which bind to class II major histocompatibility proteins and interact with T cells bearing particular V-beta chains as part of their alpha-beta-receptors. These superantigens have been suggested to be encoded by exogenous or endogenous mouse mammary tumour viruses. One such superantigen is now shown to be encoded in the open reading frame of the long terminal repeat of a mammary tumour virus, a gene of previously unknown function.

引用

页码：203 / 207

页数：5

共 52 条

[1]

ABE R, 1989, ANNU REV IMMUNOL, V7, P683, DOI 10.1146/annurev.iy.07.040189.003343

[2]

ARNOLD LW, 1983, J IMMUNOL, V131, P2064

[3] AN ANALYSIS OF T-CELL RECEPTOR VARIABLE REGION GENE-EXPRESSION IN MAJOR HISTOCOMPATIBILITY COMPLEX DISPARATE MICE [J].