MEDIATION BY G-PROTEINS OF SIGNALS THAT CAUSE COLLAPSE OF GROWTH CONES

被引：178

作者：

IGARASHI, M

STRITTMATTER, SM

VARTANIAN, T

FISHMAN, MC

机构：

[1] MASSACHUSETTS GEN HOSP E,DEV BIOL LAB,BOSTON,MA 02129

[2] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115

来源：

SCIENCE | 1993年 / 259卷 / 5091期

关键词：

D O I：

10.1126/science.8418498

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During development, motion of nerve growth cones ceases on contact with particular targets. The signaling mechanism is unknown. In culture, growth cone collapse can be caused by solubilized embryonic brain membranes, central nervous system myelin, a 35-kilodalton protein isolated from myelin, and mastoparan. Collapse induced by each of these is blocked by pertussis toxin. Thus, collapse of growth cones is mediated by G protein-coupled receptors, which may be activated by proteins associated with the cell surface as well as by soluble ligands.

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页码：77 / 79

页数：3

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